Lebenslauf
Dr. Stefan Schlatt
University of Pennsylvania
| Name | PD Dr. rer.nat. Stefan Schlatt |
| Anschrift | Pennsylvania University Center for Animal Transgenesis and Germ Cell Research, New Bolton Center, 382 West Street Rd. Kennett Square, PA 19348 USA privat: Lindkamp 13 |
| Geburtstag | 23. Februar 1964 |
| Geburtsort | Rhede, Westfalen |
| Ehefrau | Dipl. Ing. Klara Schlatt, Bauingenieurin |
| Kinder | Lukas *13. Dezember 1990 Jakob *9. September 1992 Ferdinand *6. September 1995 |
| Schulbildung | |
| 1970-1974 | St. Bernhard Grundschule, Lowick |
| 1974-1983 | St. Josef Gymnasium OFMCap, Bocholt |
| 10.06.1983 | Abitur |
| Akademische Ausbildung und wissenschaftlicher Werdegang | |
| 1983-1989 | Biologiestudium an der WWU |
| 1984-1993 | Studium der Katholischen Theologie an der WWU |
| 10.04.1986 | Vordiplom Biologie |
| 22.10.1986 | 1. Hauptprüfung in katholischer Theologie |
| 23.05.1989 | Diplom (Zoologie) |
| Thema der Diplomarbeit: | Untersuchungen zu photoperiodisch induzierten Veränderungen der Reproduktionsorgane in weiblichen Zwerghamstern Phodopus sungorus Pallas. (Max Planck Gesellschaft, Klinische Forschungsgruppe für Reproduktionsmedizin, Dr. Klaus Hoffmann |
| 01.02.1989-31.12.1991 | Wissenschaftliche Hilfskraft am Institut für Reproduktionsmedizin der WWU (Direktor: Prof. Dr. E. Nieschlag) |
| 31.3.1992 | Promotion magna cum laude (Zoologie) an der Math.Nat. Fakultät der WWU |
| Thema der Dissertation: | Immunohistochemische Lokalisation von Inhibin in Reproduktionsorganen männlicher Affen (Macaca mulatta, Macaca fascicularis). |
| 01.01.1992- 31.12.1994 | Wissenschaftlicher Mitarbeiter am Institut für Reproduktionsmedizin der WWU |
| 01.02.1995-31.01.1997 | Stipendiat (Ausbildungsstipendium der Deutschen Forschungsgemeinschaft) am Institute of Reproduction and Development der Monash University, Clayton, Australien (Direktor: Professor Dr. David de Kretser) |
| 01.03.1997-15.07.1997 | Stipendiat (Research Training Fellowship in Reproductive Biology, Wellcome Trust, London, UK) am Institute of Reproduction and Development der Monash University, Clayton, Australien |
| 15.07.1997-31.12.1999 | Wissenschaftlicher Mitarbeiter am Institut für Reproduktionsmedizin der WWU Münster 09.12.1999 Habilitation an der med. Fakultät der Universität Münster. Venia legendi: Reproduktionsbiologie |
| Thema der Habilitationsschrift: | Zellbiologische und tierexperimentelle Untersuchungen zur Rolle von Spermatogonien bei Fertilitätsstörungen und zur präklinischen Erprobung der Keimzelltransplantation als Methode zur Fertilitätserhaltung bei onkologischen Patienten |
| seit 01.01.2000 | Heisenberg-Stipendiat der Deutschen Forschungsgemeinschaft |
| seit 08.10.2000 | Forschungsaufenthalt an der Pennsylvania University, Center for Animal Transgenesis and Germ Cell Research, New Bolton Center, Kennett Square, PA, USA |
Gegliedertes Schriftenverzeichnis
1. Originalarbeiten
1) Schlatt S, Weinbauer GF, Nieschlag E. Inhibin-like and gonadotropin-like immunoreactivity in pituitary cells of male monkeys (Macaca fascicularis, Macaca mulatta). Cell Tiss Res 265: 203-209 (1991).
2) Niklowitz P, De Geyter M, Schlatt S, Hoffmann K, Nieschlag E. Pattern of pineal melatonin concentrations during prolonged exposure to short photoperiods in photosensitive and photoinsensitive Djungarian hamsters. J Pineal Res 12: 64-70 (1992).
3) Lerchl A, Schlatt S: Serotonin content and melatonin production in the pineal gland of the male Djungarian hamster (Phodopus sungorus). J Pineal Res 12: 128-134 (1992).
4) Arslan M, Weinbauer GF, Schlatt S, Shahab M, Nieschlag E. FSH and testosterone, alone or in combination, initiate testicular growth and increase the number of spermatogonia and Sertoli cells in a juvenile non-human primate (Macaca mulatta). J Endocrinol 136: 235-243 (1993).
5) Lerchl A, Schlatt S. Influence of the photoperiod on pineal melatonin synthesis, fur colour, body weight and reproductive function in the female Djungarian hamster (Phodopus sungorus). Neuroendocrinology 57: 359-367 (1993).
6) Schlatt S, Weinbauer GF, Arslan M, Nieschlag E. Appearance of alpha-smooth muscle actin in peritubular cells of monkey testes is induced by androgens, modulated by follicle stimulating hormone and maintained after hormonal withdrawal. J Androl 14: 340-350 (1993).
7) Schlatt S, Niklowitz P, Hoffmann K, Nieschlag E. Influence of short photoperiods on reproductive organs and estrous cycles of normal and pinealectomized female Djungarian hamster, Phodopus sungorus. Biol Reprod 49: 243-250 (1993).
8) Vliegen M, Schlatt S, Weinbauer GF, Bergmann M, Groome NP, Nieschlag E. Localization of inhibin/activin subunits in the testis of adult non-human primates and men. Cell Tiss Res: 273: 261-268 (1993).
9) Rosiepen G, Weinbauer GF, Schlatt S, Behre HM, Nieschlag E. Duration of the cycle of the seminiferous epithelium, estimated by the 5-bromodeoxyuridine technique, in laboratory and feral rats. J Reprod Fertil 100: 299-306 (1994).
10) Schlatt S, Weinbauer GF. Immunohistochemical detection of proliferating cell nuclear antigen as a tool to study cell proliferation in rodent and primate testes. Int J Androl 17: 214-222 (1994).
11) Brinkworth M, Weinbauer GF, Schlatt S, Nieschlag E. Identification of male germ cells undergoing apoptosis in male rats. J Reprod Fertil 105: 25-33 (1995).
12) Schlatt S, Arslan M, Weinbauer GF, Behre HM, Nieschlag E: Endocrine control of somatic cell and premeiotic germ cell development in the male rhesus monkey (Macaca mulatta). Eur J Endocrinol 133: 235-247 (1995).
13) Schlatt S, de Geyter M, Kliesch S, Nieschlag E, Bergmann M: Spontaneous recrudescence of spermatogenesis in the photoinhibited male Djungarian hamster, Phodopus sungorus. Biol Reprod 53: 169-1177 (1995)
14) Dankbar B, MH Brinkworth, S Schlatt, GF Weinbauer, E Nieschlag, J Gromoll. Ubiquitous expression of the androgen receptor and testis-specific expression of the FSH receptor in the cynomolgus monkey (Macaca fascicularis) revealed by a ribonuclease protection assay. J Steroid Biochem Mol Biol 55: 35-41 (1995).
15) Schlatt S, Loveland K, deKretser DM. Discriminative analysis of Sertoli and peritubular cells and their proliferation in vitro: Evidence for FSH-mediated contact inhibition of Sertoli cell mitosis. Biol Reprod 55, 227-235 (1996).
16) Munsie M, Schlatt S, deKretser DM, Loveland KL. Expression of stem cell factor in the postnatal rat testis. Mol Reprod Develop 47: 19-25 (1997).
17) Loveland K, Schlatt S, Sasaki T, Chu M-L, Timpl R, Dziadek M. Developmental changes in the basement membrane of the normal and hypothyroid postnatal rat testis: Segmental localization of fibulin-2 and fibronectin. Biol Reprod 58: 1123-1130 (1998).
18) Zhengwei Y, Wreford NG, Schlatt S, Weinbauer GF, Nieschlag E, McLachlan RI. Acute and specific impairment of spermatogonial development by GnRH antagonist-induced gonadotropin withdrawal in the adult macaque. J Reprod Fertil 112: 139-147 (1998).
19) Schlatt S, Rosiepen G, Weinbauer GF, Rolf C, Brook PF, Nieschlag E. Germ cell transfer into rat, bovine, monkey and human testes. Human Reproduction 14: 144-150 (1999).
20) Sch?feldt von V, Krishnamurty H, Foppiani L, Schlatt S. Magnetic cell sorting as a fast and efficient method of isolating viable spermatogonia from Djungarian hamster, mouse and marmoset monkey testes. Biol Reprod 61: 582-589 (1999).
21) Schlatt S, deKretser DM, Hedger MP. Mitosis of resident macrophages in the adult rat testis. J Reprod Fertil 116: 223-228 (1999).
lang=EN-GB 22) Foppiani L, Schlatt S, Simoni M, Weinbauer GF, Hacker-Klom U, Nieschlag. Inhibin B is a more sensitive marker of spermatogenetic damage than FSH in the irradiated non-human primate model. J Endocrinol 162: 393-400 (1999).
23) Schlatt S, Zhengwei Y, Meehan T, deKretser DM, Loveland KL. Application of morphometric techniques of postnatal rat testes in organ culture: Insights into testis growth. Cell Tiss Res 298: 335-343 (1999).
24) Gromoll J, Weinbauer GF, Skaletsky H, Schlatt S, Rocchietti-March M, Page DC, Nieschlag E. The old world monkey DAZ (Deleted in AZoospermia) gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome. Hum Mol Gen 8: 2017-2024 (1999)
25) Oryan MK, Schlatt S, Philipps DJ, deKretser DM, Hedger MP. Bacterial lipopolysaccaride-induced inflammation compromises testicular function at multiple levels in vivo. Endocrinology 141: 238-246 (2000).
26) Meehan T, Schlatt S, Oryan MK, deKretser DM, Loveland KL. Regulation of germ cell and Sertoli cell development by activin, follistatin and FSH. Develop Biol 220: 225-237 (2000).
27) O'Bryan MK, Schlatt S, Gerdprasert O, Phillips DJ, de Kretser DM, Hedger MP Inducible nitric oxide synthase in the rat testis: evidence for potential roles in both normal function and inflammation-mediated infertility. Biol Reprod. 63: 1285-1293 (2000).
28) Weinbauer GF, Schlatt S, Walter V, Nieschlag E. Testosterone-induced inhibition of spermatogenesis is more closely related to suppression of FSH than to testicular androgen levels in the cynomolgus monkey model (Macaca fascicularis). J Endocrinol 168: 25-38 (2001).
29) Wistuba J, Brinkworth MH, Schlatt S, Chahoud I, Nieschlag E. Intrauterine bisphenol A exposure leads to stimulatory effects on Sertoli cell numbers in rats. Reprod Toxicol (under revision).
30) Schlatt S, Kim S, Gosden RG. Fertile potential of murine testicular tissue after cryopreservation and isografting. Biol Reprod (under revision).
- Übersichtsarbeiten in Zeitschriften und Büchern
1) Loveland K, S Schlatt: Stem cell factor and c-kit in the mammalian testis: lessons originating from mother nature? gene knockouts. J Endocrinol 153: 337-344 (1997).
2) Schlatt S, A Meinhardt, E Nieschlag: Paracrine regulation of cellular interactions in the testis: factors in search of a function. Eur J Endocrinol 137: 107-117 (1997).
3) Schlatt S. Problems and prospects for germ cell transplantation in the male. Int J Androl 22: 13-18 (1999)
4) Schlatt S, Schönfeldt V, Nieschlag E. Germ cell transplantation in the male: Animal studies with a human perspective. Human Fertility 2: 143-148 (1999).
5) Schlatt S, Schepers A, von Schönfeldt V, Nieschlag E. Gonadal transplantation: The primate model. In: Andrology 2000, eds. F. Francavilla, S. Francavilla, G. Forti. Litografia Brandolini, Chiety, Italy, pp 193-210 (2000).
lang=EN-US 6) Schlatt S, Schepers AG, von Sch?feldt V. Germ cell culture, genetic manipulation and transplantation. In : Testis, epididymis and technologies in the year 2000. Eds. B. Jegou, C. Pineau, J. Saez. Ernst Schering Research Foundation Proceedings, Supplement 6 (2000).
7) Schlatt S, von Schönfeldt V, Schepers AG. Male germ cell transplantation: an experimental approach with a clinical perpective. Brit Med Bull 56: 824-836 (2000). 8) Eberhard Nieschlag, Andrea Wagenfeld, Viktoria v. Schönfeldt, Stefan Schlatt Keimzellspende: Möglichkeiten und Entwicklungen. Symposium Fortpflanzungsmedizin in Deutschland, BMF+T Veroeffentlichungen (2000).
8) Schlatt S. Germ cell transplantation. Mol Cell Endocrinol (in press).
9) Meachem S, von Schönfeldt V, Schlatt S. Spermatogonia: a stem cell with a great perspective. Reproduction 121: 825-834 (2001).
10) Schlatt S, Nieschlag E. Keimzelltransplantation als Methode zur Fertilitätsbehandlung bei onkologischen Patienten. Klin Piatr 213: 250-254 (2001).